Proteins are complex bio-molecules responsible for a great number of functions in the human body. Each protein has a specific task it must accomplish – signaling, regulation, transcription or...
What is ASFD?
Atmospheric Spray Freeze Drying (ASFD) is an alternative to conventional lyophilization and spray drying methods for improved shelf stability.
- Faster processing compared to lyophilization (hours not days)
- Gentler on proteins compared to spray drying (no high heat)
- Result is a loose, flowing powder, not a cake requiring additional processing
Improved particle properties
- Aerodynamic for consistent, targeted delivery via the pulmonary or nasal routes
- High surface area for rapid reconstitution
- Ideal for self-administration devices
Improved economics and better control of the process
- No need for the complex vacuum systems of lyophilization
- Low temperatures means higher viable protein yields compared to spray drying
- Protein based pharmaceuticals with poor shelf-stability
- Pulmonary targets (antibiotics, vaccines, cancer treatments, asthma medications, etc.)
- Accessing systemic circulation through pulmonary routes (insulin, antibiotics, cancer treatments, etc.)
- Nasal cavity targets (vaccines)